Skin rash following levetiracetam
نویسندگان
چکیده
A 19-year-old woman had secondary generalized seizures for 18 months due to a calcified parietal granuloma. She was treated with phenytoin (PHT) and sodium valproate. PHT was replaced with LEV 500 mg twice daily because of a recurrence of seizures. Having taken LEV for 10 days, she developed a generalized maculopapular itchy rash which spared the mucous membranes. LEV was stopped and she was prescribed oral cetirizine, ranitidine, and clobazam. Sodium valproate was continued. The skin rash improved over the next 5 days, but she had break through seizures. LEV was restarted at a dose of 750 mg twice daily. On day 7 of LEV administration, she again developed a maculopapular rash this time also affecting the mucus membranes. The skin rash involved more than 70% of body surface area. Her Naranjo score was nine, suggesting a definite association between LEV and skin rash. The patient was managed in intensive care and required nasogastric tube feeding. She was given oxygen by face mask and LEV and sodium valproate was stopped. She received intravenous immunoglobulin 200 mg/kg daily for 5 days, topical steroid ointment, artificial tear and levocetirizine 10 mg daily. After 1 month of hospital treatment, her rash had healed sufficiently for her to be discharged. She remained seizure free for next 1 year on clobazam 15 mg twice daily.
منابع مشابه
Levetiracetam induced angioedema in a patient with previous anticonvulsant hypersensitivity reaction to phenytoin and lamotrigine
Allergic reactions to antiepileptic drugs in the form of skin rash are not uncommon but angioedema, an acute life threatening reaction is rare. Angioedema has been reported with the use of oxcarbazepine and carbamazepine. We report a case of a 33-year-old woman with focal epilepsy who developed angioedema following levetiracetam monotherapy. The patient had previous skin rashes with both phenyt...
متن کاملDiphenylhydantoin Induced DRESS Syndrome: A Case Report.
Drug Rash with Eosinophilia and Systemic Symptoms" (DRESS) syndrome is a severe adverse drug reaction. The drugs most often implicated are anti-convulsants, bupropion, sulfonamides, sulfasalazine, allopurinol, minocycline, abacavir and neviparine. There are also immune and infectious causes that can lead to DRESS syndrome. A 70-year-old female patient had undergone endovascular coil embolizatio...
متن کاملCross-reactivity of skin rashes with current antiepileptic drugs in Chinese population
OBJECTIVE Due to less experience with the cross-reactivity of antiepileptic drugs (AEDs) in Chinese population, we surveyed the rates of cross- reactivity of rash among commonly used AEDs in Chinese patients with epilepsy, particularly between the traditional and the new compounds. METHODS We have retrospectively reviewed the medical records concerning all antiepileptic drug treatment in cons...
متن کاملSingle centre 20 year survey of antiepileptic drug-induced hypersensitivity reactions.
BACKGROUND Epilepsy is a chronic neurological disease which affects about 1% of the human population. There are 50 million patients in the world suffering from this disease and 2 million new cases per year are observed. The necessary treatment with antiepileptic drugs (AEDs) increases the risk of adverse reactions. In case of 15% of people receiving AEDs, cutaneous reactions, like maculopapular...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Seizure
دوره 37 شماره
صفحات -
تاریخ انتشار 2016